Compound Detail
CHEMBL3103867
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Basic Information
| ChEMBL ID | CHEMBL3103867 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XFUKFDJFEAQRRG-AWEZNQCLSA-N |
4
Targets
4
Activities
2
Assay Types
2
PK Parameters
12
Publications
0
Known Names
Molecular Properties
406.5
MW (Da)
3.04
ALogP
6
HBA
3
HBD
110.2
PSA (Ų)
0.61
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 10.52
IC50 1 meas. best 6.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | Ki | 10.52 | 10.52 | 0.0 | 1 |
| Serine/threonine-protein kinase pim-3 CHEMBL5407 | Ki | 10.22 | 10.22 | 0.1 | 1 |
| Serine/threonine-protein kinase pim-2 CHEMBL4523 | Ki | 9.7 | 9.7 | 0.2 | 1 |
| MM1.S CHEMBL4296471 | IC50 | 6.8 | 6.8 | 160.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 15.0 | mL.min-1.kg-1 | Rattus norvegicus |
| F | 54.0 | % | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 | Ki | = | 0.03 | nM | 10.52 | Inhibition of recombinant human PIM1 using FAM-pimtide as substrate after 90 min... | 30715878 |
| Serine/threonine-protein kinase pim-3 | Ki | = | 0.06 | nM | 10.22 | Inhibition of recombinant human PIM3 using FAM-pimtide as substrate after 90 min... | 30715878 |
| Serine/threonine-protein kinase pim-2 | Ki | = | 0.2 | nM | 9.7 | Inhibition of recombinant human PIM2 using FAM-pimtide as substrate after 90 min... | 30715878 |
| MM1.S | IC50 | = | 160.0 | nM | 6.8 | Antiproliferative activity against human MM1S cells after 72 hrs by CellTiter-Gl... | 30715878 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30715878 | 10.1021/acs.jmedchem.8b01857 | ADMET | 5 |
| 24900629 | 10.1021/ml400307j | Serine/threonine-protein kinase pim-3 | 1 |
| 24900629 | 10.1021/ml400307j | Serine/threonine-protein kinase pim-2 | 1 |
| 24900629 | 10.1021/ml400307j | Serine/threonine-protein kinase pim-1 | 1 |
| 26995528 | 10.1016/j.bmcl.2016.03.037 | Serine/threonine-protein kinase pim-1 | 1 |
| 26995528 | 10.1016/j.bmcl.2016.03.037 | Serine/threonine-protein kinase pim-2 | 1 |
| 26995528 | 10.1016/j.bmcl.2016.03.037 | Serine/threonine-protein kinase pim-3 | 1 |
| 30715878 | 10.1021/acs.jmedchem.8b01857 | Serine/threonine-protein kinase pim-2 | 1 |
| 30715878 | 10.1021/acs.jmedchem.8b01857 | Serine/threonine-protein kinase pim-1 | 1 |
| 30715878 | 10.1021/acs.jmedchem.8b01857 | Serine/threonine-protein kinase pim-3 | 1 |
| 30715878 | 10.1021/acs.jmedchem.8b01857 | MM1.S | 1 |
| 30715878 | 10.1021/acs.jmedchem.8b01857 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine