Assay Detail
Binding
CHEMBL1919488
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to PKCtheta C1B subdomain after 1 hr by fluorescence quenching analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Binding of isoxazole and pyrazole derivatives of curcumin with the activator binding domain of novel protein kinase C.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.15 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL181529 | — | — | 1 | 5.50 |
| CHEMBL1914610 | — | — | 1 | 5.15 |
| CHEMBL180239 | CURCUMIN PYRAZOLE | — | 1 | 5.14 |
| CHEMBL1914609 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL181529 | — | EC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL1914610 | — | EC50 | = | 7140.0 | nM | 5.15 |
| CHEMBL180239 | CURCUMIN PYRAZOLE | EC50 | = | 7250.0 | nM | 5.14 |
| CHEMBL1914609 | — | EC50 | = | 15840.0 | nM | 4.80 |