Assay Detail
Functional
CHEMBL1920036
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Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 2-indolinone derivatives as potential antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 4.91 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1914686 | — | — | 1 | 5.64 |
| CHEMBL1914690 | — | — | 1 | 5.37 |
| CHEMBL1914687 | — | — | 1 | 5.28 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 5.21 |
| CHEMBL1914685 | — | — | 1 | 5.09 |
| CHEMBL1914911 | — | — | 1 | 5.07 |
| CHEMBL1914676 | — | — | 1 | 5.04 |
| CHEMBL1914683 | — | — | 1 | 5.04 |
| CHEMBL1914689 | — | — | 1 | 5.02 |
| CHEMBL1914677 | — | — | 1 | 4.96 |
| CHEMBL1914675 | — | — | 1 | 4.91 |
| CHEMBL1914688 | — | — | 1 | 4.89 |
| CHEMBL1914906 | — | — | 1 | 4.87 |
| CHEMBL1914907 | — | — | 1 | 4.75 |
| CHEMBL1914681 | — | — | 1 | 4.74 |
| CHEMBL1914905 | — | — | 1 | 4.65 |
| CHEMBL1914908 | — | — | 1 | 4.65 |
| CHEMBL1914682 | — | — | 1 | 4.59 |
| CHEMBL1914910 | — | — | 1 | 4.55 |
| CHEMBL1914684 | — | — | 1 | 4.46 |
| CHEMBL1914909 | — | — | 1 | 4.38 |
| CHEMBL1914679 | — | — | 1 | - |
| CHEMBL1914678 | — | — | 1 | - |
| CHEMBL1914691 | — | — | 1 | - |
| CHEMBL1914904 | — | — | 1 | - |
| CHEMBL1914680 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1914686 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1914690 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL1914687 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL535 | SUNITINIB | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL1914685 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL1914911 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL1914676 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL1914683 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL1914689 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL1914677 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1914675 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL1914688 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL1914906 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL1914907 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL1914681 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL1914905 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL1914908 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL1914682 | — | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL1914910 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL1914684 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL1914909 | — | IC50 | = | 42100.0 | nM | 4.38 |
| CHEMBL1914679 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1914678 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1914691 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1914904 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1914680 | — | IC50 | > | 50000.0 | nM | - |