Assay Detail
Binding
CHEMBL1920125
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine aortic PDE5 using cGMP as substrate in presence of EGTA
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL3478) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
New PDE4 inhibitors based on pharmacophoric similarity between papaverine and tofisopam.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.90 | 4.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1915065 | GIRISOPAM | 2.0 | 1 | 4.90 |
| CHEMBL1915066 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1915065 | GIRISOPAM | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL1915066 | — | IC50 | - | — | - |