Compound Detail
CHEMBL1915065
GIRISOPAM 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL1915065 |
| Name | GIRISOPAM |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | VQYLGVVODFDFNK-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
2
Known Names
Molecular Properties
328.8
MW (Da)
4.13
ALogP
4
HBA
0
HBD
43.2
PSA (Ų)
0.85
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 3 meas. best 5.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.5 | 5.45 | 3200.0 | 2 |
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL3478 | IC50 | 4.9 | 4.9 | 12500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 3200.0 | nM | 5.5 | Inhibition of bovine aortic PDE4 using cAMP as substrate in presence of cGMP | 21920746 |
| Unchecked | IC50 | = | 4000.0 | nM | 5.4 | Inhibition of bovine aortic endothelial cells PDE2 using cAMP as substrate in pr... | 21920746 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 12500.0 | nM | 4.9 | Inhibition of bovine aortic PDE5 using cGMP as substrate in presence of EGTA | 21920746 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21920746 | 10.1016/j.bmcl.2011.08.036 | Unchecked | 4 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 4 |
| - | 10.6019/CHEMBL4651402 | Vero C1008 | 2 |
| 21920746 | 10.1016/j.bmcl.2011.08.036 | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
Data from ChEMBL 36 via Core Engine