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Assay Detail

CHEMBL1920651

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of jack bean alpha-mannosidase assessed as p-nitrophenol release using p-nitrophenyl-alpha-D-mannopyranoside as substrate after 15 to 60 mins by spectrophotometry
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Canavalia ensiformis
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis of anomeric 1,5-anhydrosugars as conformationally locked selective α-mannosidase inhibitors.
Mane RS, Ghosh S, Singh S, Chopade BA, Dhavale DD.
Bioorg Med Chem (2011) 19 : 6720 -6725
PubMed 22001328 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.00 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL371197 TRIDOLGOSIR 2.0 1 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL371197 TRIDOLGOSIR IC50 = 100.0 nM 7.00