Compound Detail
CHEMBL371197
TRIDOLGOSIR 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL371197 |
| Name | TRIDOLGOSIR |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | FXUAIOOAOAVCGD-WCTZXXKLSA-N |
7
Targets
15
Activities
2
Assay Types
0
PK Parameters
20
Publications
2
Known Names
Molecular Properties
173.2
MW (Da)
-1.45
ALogP
4
HBA
3
HBD
63.9
PSA (Ų)
0.42
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Activity Summary
IC50 10 meas. best 8.3
Ki 5 meas. best 8.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform B CHEMBL1697673 | Ki | 8.52 | 8.52 | 3.0 | 1 |
| Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform B CHEMBL1697673 | IC50 | 8.3 | 8.3 | 5.0 | 1 |
| Lysosomal alpha-mannosidase CHEMBL4059 | IC50 | 8.0 | 6.6667 | 10.0 | 3 |
| Unchecked CHEMBL612545 | IC50 | 7.96 | 7.44 | 11.0 | 4 |
| Unchecked CHEMBL612545 | Ki | 7.7 | 7.255 | 20.0 | 2 |
| Alpha-mannosidase CHEMBL4193 | IC50 | 6.4 | 6.4 | 400.0 | 1 |
| Alpha-mannosidase 2C1 CHEMBL2852 | IC50 | 5.76 | 5.76 | 1750.0 | 1 |
| Alpha-1,2-mannosidase (BT_3990) CHEMBL5316241 | Ki | 5.3 | 5.3 | 5000.0 | 1 |
| Alpha-1,2-mannosidase (BT_2199) CHEMBL5316242 | Ki | 4.85 | 4.85 | 14000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine