Assay Detail
Binding
CHEMBL832759
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Concentration of compound inhibiting alpha-Mannosidase isolated from Jack bean
16
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canavalia ensiformis |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Functionalized pyrrolidines inhibit alpha-mannosidase activity and growth of human glioblastoma and melanoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.86 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371197 | TRIDOLGOSIR | 2.0 | 1 | 6.40 |
| CHEMBL425723 | — | — | 1 | 6.16 |
| CHEMBL425364 | — | — | 2 | 5.52 |
| CHEMBL190736 | — | — | 1 | 5.21 |
| CHEMBL190418 | — | — | 2 | 5.16 |
| CHEMBL190634 | — | — | 1 | 4.77 |
| CHEMBL435112 | — | — | 1 | 4.26 |
| CHEMBL190311 | — | — | 1 | 4.22 |
| CHEMBL363475 | — | — | 1 | 4.22 |
| CHEMBL191531 | — | — | 1 | 4.20 |
| CHEMBL193028 | — | — | 1 | 4.05 |
| CHEMBL189366 | — | — | 1 | 4.00 |
| CHEMBL188227 | — | — | 1 | - |
| CHEMBL361899 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371197 | TRIDOLGOSIR | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL425723 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL425364 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL425364 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL190736 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL190418 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL190634 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL190418 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL435112 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL190311 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL363475 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL191531 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL193028 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL189366 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL188227 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL361899 | — | IC50 | = | 128000.0 | nM | - |