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Target Snapshot

CHEMBL4193 Target Snapshot

Alpha-mannosidase · SINGLE PROTEIN · Glycine max

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82Compounds
39Assays
0Approved Drugs
97.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9SEH8. Use UniProt Q9SEH8 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9SEH8 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Alpha-mannosidase as ChEMBL target CHEMBL4193, mapped to UniProt Q9SEH8. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Alpha-mannosidase
SINGLE PROTEIN · Glycine max
As of 2026-09-14
ChEMBL target ID
CHEMBL4193
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9SEH8
alpha-1,2-Mannosidase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Alpha-mannosidase is the right protein anchor across sources, using UniProt Q9SEH8 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameAlpha-mannosidase
Target TypeSINGLE PROTEIN
OrganismGlycine max
UniProtQ9SEH8
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Labelalpha-1,2-Mannosidase
UniProt AccessionQ9SEH8
Component TypeProtein
Sequence Length578 aa

alpha-1,2-Mannosidase

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Alpha-mannosidase, mapped to UniProt Q9SEH8. ChEMBL maps the protein component as alpha-1,2-Mannosidase. Sequence length is 578 aa.

Mapped IDQ9SEH8
Review nameAlpha-mannosidase
OrganismGlycine max
Clinical Profile

Clinical Phase Distribution

1
Phase II
Assay Mix

Activity Type Distribution

IC5055.0
KI42.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL190311 7.72 Ki 19.0 Preclinical
CHEMBL425723 6.87 Ki 135.0 Preclinical
CHEMBL371197 6.4 IC50 400.0 Clinical
CHEMBL425723 6.16 IC50 700.0 Preclinical
CHEMBL190736 5.92 Ki 1200.0 Preclinical
CHEMBL425364 5.87 Ki 1350.0 Preclinical
CHEMBL190634 5.64 Ki 2300.0 Preclinical
CHEMBL425364 5.52 IC50 3000.0 Preclinical
CHEMBL190736 5.21 IC50 6200.0 Preclinical
CHEMBL190418 5.16 IC50 7000.0 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
4
5.5
2
6.0
1
6.5
0
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

39
Total Assays
34
Tested Compounds
2
Assay Types
Binding — 33 assays, 34 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 33 34 4.8
Functional — 6 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 6 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine