Assay Detail
Binding
CHEMBL987284
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Inhibition of jack bean alpha-mannosidase
6
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canavalia ensiformis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Functionalized pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: optimizing the fit to the active site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.44 | 6.87 |
| IC50 | 2 | 6.78 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371197 | TRIDOLGOSIR | 2.0 | 2 | 7.40 |
| CHEMBL425723 | — | — | 2 | 6.87 |
| CHEMBL476926 | — | — | 1 | 6.69 |
| CHEMBL476925 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371197 | TRIDOLGOSIR | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL425723 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL371197 | TRIDOLGOSIR | Ki | = | 155.0 | nM | 6.81 |
| CHEMBL476926 | — | Ki | = | 206.0 | nM | 6.69 |
| CHEMBL425723 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL476925 | — | Ki | = | 4000.0 | nM | 5.40 |