Assay Detail
Binding
CHEMBL987286
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Inhibition of alpha-mannosidase in human LNZ308 cells
9
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LNZ308 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Functionalized pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: optimizing the fit to the active site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.81 | 6.30 |
| Ki | 2 | 5.32 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL476926 | — | — | 2 | 6.30 |
| CHEMBL476343 | — | — | 1 | 5.12 |
| CHEMBL371197 | TRIDOLGOSIR | 2.0 | 1 | 4.70 |
| CHEMBL425723 | — | — | 2 | 4.38 |
| CHEMBL476925 | — | — | 1 | 4.30 |
| CHEMBL476718 | — | — | 1 | 4.12 |
| CHEMBL476927 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL476926 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL476926 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL476343 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL371197 | TRIDOLGOSIR | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL425723 | — | Ki | = | 41500.0 | nM | 4.38 |
| CHEMBL476925 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL425723 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL476718 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL476927 | — | IC50 | = | 150000.0 | nM | - |