Lysosomal alpha-mannosidase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt O00754. Use UniProt O00754 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O00754 as the stable identity anchor, then attach disease evidence before program review.
Lysosomal alpha-mannosidase
Review this target as Lysosomal alpha-mannosidase, mapped to UniProt O00754. Sequence length is 1011 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Lysosomal alpha-mannosidase as ChEMBL target CHEMBL4059, mapped to UniProt O00754. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Lysosomal alpha-mannosidase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O00754 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Lysosomal alpha-mannosidase |
| UniProt Accession | O00754 |
| Component Type | Protein |
| Sequence Length | 1011 aa |
Lysosomal alpha-mannosidase
Review this target as Lysosomal alpha-mannosidase, mapped to UniProt O00754. Sequence length is 1011 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL371197 | 8.0 | IC50 | 10.0 | Clinical |
| CHEMBL4465842 | 6.36 | IC50 | 440.0 | Preclinical |
| CHEMBL476926 | 6.3 | IC50 | 500.0 | Preclinical |
| CHEMBL476926 | 6.26 | Ki | 550.0 | Preclinical |
| CHEMBL476343 | 6.12 | IC50 | 750.0 | Preclinical |
| CHEMBL4462117 | 5.66 | IC50 | 2200.0 | Preclinical |
| CHEMBL4475419 | 4.76 | IC50 | 17300.0 | Preclinical |
| CHEMBL4457217 | 4.71 | IC50 | 19300.0 | Preclinical |
| CHEMBL425723 | 4.63 | Ki | 23300.0 | Preclinical |
| CHEMBL425723 | 4.6 | IC50 | 25000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 33 | 16 | 5.1 |
| assay format | 15 | 0 | — |
| cell-based format | 2 | 7 | 5.1 |
| subcellular format | 2 | 7 | 5.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 0 | — |