Assay Detail
Binding
CHEMBL987285
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Inhibition of drosophila golgi alpha-mannosidase 2
6
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Drosophila |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Functionalized pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: optimizing the fit to the active site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.63 | 7.70 |
| IC50 | 2 | 5.75 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371197 | TRIDOLGOSIR | 2.0 | 2 | 7.70 |
| CHEMBL476926 | — | — | 1 | 6.00 |
| CHEMBL476925 | — | — | 1 | 4.66 |
| CHEMBL425723 | — | — | 2 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371197 | TRIDOLGOSIR | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL371197 | TRIDOLGOSIR | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL476926 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL476925 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL425723 | — | Ki | = | 67000.0 | nM | 4.17 |
| CHEMBL425723 | — | IC50 | = | 80000.0 | nM | 4.10 |