Assay Detail
Functional
CHEMBL1920682
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Antiproliferative activity against human NCI-H1373 cells after 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1373 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Activation of the c-Jun N-terminal kinase/activating transcription factor 3 (ATF3) pathway characterizes effective arylated diazeniumdiolate-based nitric oxide-releasing anticancer prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.76 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL455983 | — | — | 1 | 6.07 |
| CHEMBL212378 | — | — | 1 | 6.02 |
| CHEMBL1917522 | — | — | 1 | 5.73 |
| CHEMBL1917524 | — | — | 1 | 5.68 |
| CHEMBL1917523 | — | — | 1 | 5.52 |
| CHEMBL1917525 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL455983 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL212378 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL1917522 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL1917524 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1917523 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1917525 | — | IC50 | = | 3080.0 | nM | 5.51 |