Assay Detail
Functional
CHEMBL1920722
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against P-gp-negative human KB-3-1 cells after 72 hrs by MTT assay in presence of 100 uM TQR
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB 3-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity evaluation of isatin-β-thiosemicarbazones with improved selective activity toward multidrug-resistant cells expressing P-glycoprotein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.92 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1915697 | — | — | 1 | 5.00 |
| CHEMBL504574 | — | — | 1 | 4.92 |
| CHEMBL1915706 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1915697 | — | IC50 | = | 10010.0 | nM | 5.00 |
| CHEMBL504574 | — | IC50 | = | 12090.0 | nM | 4.92 |
| CHEMBL1915706 | — | IC50 | = | 14270.0 | nM | 4.85 |