Assay Detail
Binding
CHEMBL1921067
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of BODIPY-Bak conjugated peptide from GST-tagged human Bcl-2-like protein 1 L130G mutant expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by fluorescence polarization competition assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BL21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Biochemical and pharmacological profiling of the pro-survival protein Bcl-xL.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.86 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1916191 | — | — | 1 | 7.09 |
| CHEMBL1916193 | — | — | 1 | 7.08 |
| CHEMBL192571 | — | — | 1 | 7.07 |
| CHEMBL1916190 | — | — | 1 | 7.00 |
| CHEMBL1916192 | — | — | 1 | 6.85 |
| CHEMBL221854 | — | — | 1 | 6.70 |
| CHEMBL1916194 | — | — | 1 | 6.55 |
| CHEMBL376408 | ABT 737 | 1.0 | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1916191 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL1916193 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL192571 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL1916190 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL1916192 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL221854 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL1916194 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL376408 | ABT 737 | Ki | = | 290.0 | nM | 6.54 |