Assay Detail
Functional
CHEMBL1921081
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B infected in human MT2 cells assessed as inhibition of p24 production after 4 days by ELISA
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis and biological evaluation of 3-substituted 2,5-dimethyl-N-(3-(1H-tetrazol-5-yl)phenyl)pyrroles as novel potential HIV-1 gp41 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 4.94 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1917733 | — | — | 1 | 5.66 |
| CHEMBL405828 | — | — | 1 | 5.62 |
| CHEMBL1917570 | — | — | 1 | 5.50 |
| CHEMBL1917735 | — | — | 1 | 5.39 |
| CHEMBL1917571 | — | — | 1 | 5.22 |
| CHEMBL1917573 | — | — | 1 | 5.20 |
| CHEMBL1917572 | — | — | 1 | 5.17 |
| CHEMBL526168 | — | — | 1 | 5.11 |
| CHEMBL1917574 | — | — | 1 | 5.01 |
| CHEMBL1917734 | — | — | 1 | 4.91 |
| CHEMBL1917731 | — | — | 1 | 4.88 |
| CHEMBL1917569 | — | — | 1 | 4.76 |
| CHEMBL1917568 | — | — | 1 | 4.75 |
| CHEMBL1917730 | — | — | 1 | 4.62 |
| CHEMBL1917732 | — | — | 1 | 4.59 |
| CHEMBL1917567 | — | — | 1 | 4.53 |
| CHEMBL1914492 | — | — | 1 | 4.32 |
| CHEMBL1917737 | — | — | 1 | 4.31 |
| CHEMBL1917736 | — | — | 1 | 4.29 |
| CHEMBL1917566 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1917733 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL405828 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1917570 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1917735 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL1917571 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1917573 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL1917572 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL526168 | — | EC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL1917574 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL1917734 | — | EC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL1917731 | — | EC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL1917569 | — | EC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL1917568 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1917730 | — | EC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL1917732 | — | EC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL1917567 | — | EC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL1914492 | — | EC50 | = | 47900.0 | nM | 4.32 |
| CHEMBL1917737 | — | EC50 | = | 48900.0 | nM | 4.31 |
| CHEMBL1917736 | — | EC50 | = | 51600.0 | nM | 4.29 |
| CHEMBL1917566 | — | EC50 | - | — | - |