Assay Detail
Binding
CHEMBL1921132
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Inhibition of human recombinant AChE after 5 mins using spectrophotometer by Ellman's method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.70 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1618217 | — | — | 1 | 7.00 |
| CHEMBL1618106 | — | — | 1 | 6.57 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.30 |
| CHEMBL1917825 | — | — | 1 | 5.66 |
| CHEMBL1917826 | — | — | 1 | 5.34 |
| CHEMBL1256415 | — | — | 1 | 4.98 |
| CHEMBL1914495 | — | — | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1618217 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1618106 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL95 | TACRINE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1917825 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1917826 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL1256415 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL1914495 | — | IC50 | = | 89100.0 | nM | 4.05 |