Assay Detail
Binding
CHEMBL1921242
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of BODIPY-Bak conjugated peptide from GST-tagged human Bcl-2-like protein 1 V141A mutant expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by fluorescence polarization competition assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BL21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Biochemical and pharmacological profiling of the pro-survival protein Bcl-xL.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.57 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376408 | ABT 737 | 1.0 | 1 | 6.72 |
| CHEMBL192571 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376408 | ABT 737 | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL192571 | — | Ki | = | 390.0 | nM | 6.41 |