Assay Detail
Binding
CHEMBL1921249
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of BODIPY-Bak conjugated peptide from GST-tagged mouse wild type MCL1 expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by fluorescence polarization competition assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BL21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (CHEMBL5768) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Biochemical and pharmacological profiling of the pro-survival protein Bcl-xL.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.73 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1916191 | — | — | 1 | 5.82 |
| CHEMBL1916190 | — | — | 1 | 5.70 |
| CHEMBL1916193 | — | — | 1 | 5.70 |
| CHEMBL1916194 | — | — | 1 | 5.70 |
| CHEMBL221854 | — | — | 1 | - |
| CHEMBL1916192 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1916191 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL1916190 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL1916193 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL1916194 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL221854 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1916192 | — | Ki | > | 10000.0 | nM | - |