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Assay Detail

CHEMBL1924399

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against mouse NIH/3T3 cells
21
Total Activities
21
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Mus musculus
Cell Type NIH3T3
Confidence 1 — Organism
Curated By Autocuration

Target

NIH3T3 (CHEMBL614822)
Type CELL-LINE
Organism Mus musculus

Publication

Identification of small-molecule inhibitors of Trypansoma cruzi replication.
Germain AR, Carmody LC, Dockendorff C, Galan-Rodriguez C, Rodriguez A, Johnston S, Bittker JA, MacPherson L, Dandapani S, Palmer M, Schreiber SL, Munoz B.
Bioorg Med Chem Lett (2011) 21 : 7197 -7200
PubMed 22018462 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.27 4.71
Activity 5 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1794269 1 4.71
CHEMBL1431319 1 4.38
CHEMBL1705872 1 4.33
CHEMBL1732272 1 4.29
CHEMBL1703363 1 4.28
CHEMBL1726621 1 4.21
CHEMBL1708352 1 4.20
CHEMBL1710224 1 4.19
CHEMBL1433324 1 4.15
CHEMBL1733202 1 4.13
CHEMBL1619691 1 4.11
CHEMBL1404654 1 -
CHEMBL1415084 1 -
CHEMBL1794268 1 -
CHEMBL1794238 1 -
CHEMBL1921857 1 -
CHEMBL1328878 1 -
CHEMBL1721356 1 -
CHEMBL1193142 1 -
CHEMBL1372575 1 -
CHEMBL1459090 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1794269 IC50 = 19500.0 nM 4.71
CHEMBL1431319 IC50 = 41700.0 nM 4.38
CHEMBL1705872 IC50 = 47000.0 nM 4.33
CHEMBL1732272 IC50 = 51000.0 nM 4.29
CHEMBL1703363 IC50 = 52700.0 nM 4.28
CHEMBL1726621 IC50 = 61600.0 nM 4.21
CHEMBL1708352 IC50 = 63300.0 nM 4.20
CHEMBL1710224 IC50 = 64700.0 nM 4.19
CHEMBL1433324 IC50 = 70300.0 nM 4.15
CHEMBL1733202 IC50 = 74300.0 nM 4.13
CHEMBL1619691 IC50 = 77300.0 nM 4.11
CHEMBL1404654 IC50 - -
CHEMBL1415084 Activity - -
CHEMBL1794268 IC50 - -
CHEMBL1794238 IC50 - -
CHEMBL1921857 IC50 - -
CHEMBL1328878 Activity - -
CHEMBL1721356 Activity - -
CHEMBL1193142 IC50 = 164000.0 nM -
CHEMBL1372575 Activity - -
CHEMBL1459090 Activity - -