Assay Detail
Binding
CHEMBL1925012
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Inhibition of ERalpha
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Investigation of the diastereomerism of dihydrobenzoxathiin SERMs for ER alpha by molecular modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 9.09 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL183467 | — | — | 1 | 9.40 |
| CHEMBL182980 | — | — | 1 | 9.30 |
| CHEMBL367350 | — | — | 1 | 9.30 |
| CHEMBL182794 | — | — | 1 | 9.30 |
| CHEMBL367574 | — | — | 1 | 9.15 |
| CHEMBL369545 | — | — | 1 | 9.15 |
| CHEMBL183263 | — | — | 1 | 9.15 |
| CHEMBL180300 | — | — | 1 | 8.89 |
| CHEMBL180792 | — | — | 1 | 8.77 |
| CHEMBL183584 | — | — | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL183467 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL182980 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL367350 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL182794 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL367574 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL369545 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL183263 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL180300 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL180792 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL183584 | — | IC50 | = | 3.0 | nM | 8.52 |