Assay Detail
Binding
CHEMBL1925808
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human topoisomerase 1-mediated relaxation of supercoiled pBR322 DNA
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 2 | - | - |
| IC50 | 1 | 5.21 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL479291 | UNGEREMINE | — | 1 | 5.21 |
| CHEMBL400092 | LYCORINE | — | 1 | - |
| CHEMBL469648 | VITTATINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL479291 | UNGEREMINE | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL400092 | LYCORINE | Inhibition | - | % | - | |
| CHEMBL469648 | VITTATINE | Inhibition | - | % | - |