Assay Detail
Binding
CHEMBL1925856
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Inhibition of Abl using DAIpYAAPFAKKK phosphopeptide as substrate by MALDI-MS analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and docking study of 2-phenylaminopyrimidine Abl tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.83 | 6.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL941 | IMATINIB | 4.0 | 1 | 6.63 |
| CHEMBL1923082 | — | — | 1 | 5.96 |
| CHEMBL20926 | — | — | 1 | 4.90 |
| CHEMBL1923084 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL941 | IMATINIB | IC50 | = | 234.0 | nM | 6.63 |
| CHEMBL1923082 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL20926 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL1923084 | — | IC50 | > | 25000.0 | nM | - |