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Assay Detail

CHEMBL1926178

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Binding
Binding affinity to dopamine D4 receptor in Wistar rat brain slices
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

D(4) dopamine receptor (CHEMBL3361)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Evaluation of 18F-labeled benzodioxine piperazine-based dopamine D4 receptor ligands: lipophilicity as a determinate of nonspecific binding.
Kügler F, Sihver W, Ermert J, Hübner H, Gmeiner P, Prante O, Coenen HH.
J Med Chem (2011) 54 : 8343 -8352
PubMed 22039961 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 8.59 8.59

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL7927 FAUC 113 1 8.59

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL7927 FAUC 113 Ki = 2.6 nM 8.59