D(4) dopamine receptor · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P30729. Use UniProt P30729 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P30729 as the stable identity anchor, then attach disease evidence before program review.
D(4) dopamine receptor
Review this target as D(4) dopamine receptor, mapped to UniProt P30729. Sequence length is 387 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats D(4) dopamine receptor as ChEMBL target CHEMBL3361, mapped to UniProt P30729. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | D(4) dopamine receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P30729 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | D(4) dopamine receptor |
| UniProt Accession | P30729 |
| Component Type | Protein |
| Sequence Length | 387 aa |
D(4) dopamine receptor
Review this target as D(4) dopamine receptor, mapped to UniProt P30729. Sequence length is 387 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1270323 | 9.47 | Ki | 0.34 | Preclinical |
| CHEMBL267014 | 9.37 | Ki | 0.43 | Preclinical |
| CHEMBL2037521 | 9.1 | Ki | 0.8 | Preclinical |
| CHEMBL1270423 | 9.03 | Ki | 0.93 | Preclinical |
| CHEMBL3289646 | 8.96 | Ki | 1.096 | Preclinical |
| CHEMBL71724 | 8.85 | Ki | 1.4 | Preclinical |
| CHEMBL435949 | 8.85 | Ki | 1.4 | Preclinical |
| CHEMBL53 | 8.82 | EC50 | 1.5 | Approved |
| CHEMBL1940402 | 8.82 | Ki | 1.5 | Preclinical |
| CHEMBL1270121 | 8.82 | Ki | 1.52 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 16 | 107 | 7.5 |
| cell-based format | 10 | 41 | 7.5 |
| assay format | 5 | 1 | 8.6 |
| tissue-based format | 4 | 0 | — |
| cell membrane format | 1 | 11 | 6.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 5 | 7 | 7.7 |