Compound Detail
CHEMBL267014
L-745870 Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL267014 |
| Name | L-745870 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OGJGQVFWEPNYSB-UHFFFAOYSA-N |
19
Targets
98
Activities
3
Assay Types
9
PK Parameters
20
Publications
0
Known Names
Molecular Properties
326.8
MW (Da)
3.54
ALogP
3
HBA
1
HBD
35.2
PSA (Ų)
0.80
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 90 meas. best 9.4
IC50 6 meas. best 7.37
EC50 2 meas. best 7.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(4) dopamine receptor CHEMBL219 | Ki | 9.4 | 9.1518 | 0.4 | 22 |
| Unchecked CHEMBL612545 | Ki | 9.37 | 6.8264 | 0.4 | 14 |
| D(4) dopamine receptor CHEMBL3361 | Ki | 9.37 | 8.9 | 0.4 | 2 |
| D(4) dopamine receptor CHEMBL219 | EC50 | 7.57 | 6.61 | 27.0 | 2 |
| D(4) dopamine receptor CHEMBL219 | IC50 | 7.37 | 6.748 | 42.7 | 5 |
| Sigma non-opioid intracellular receptor 1 CHEMBL287 | Ki | 7.0 | 6.9633 | 100.0 | 3 |
| Alpha-2B adrenergic receptor CHEMBL1942 | Ki | 6.8 | 6.8 | 160.0 | 1 |
| Alpha-2A adrenergic receptor CHEMBL1867 | Ki | 6.77 | 6.77 | 170.0 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | Ki | 6.7 | 6.52 | 200.0 | 2 |
| Serotonin 2 (5-HT2) receptor CHEMBL2095200 | Ki | 6.7 | 6.7 | 200.0 | 1 |
| 5-hydroxytryptamine receptor 7 CHEMBL3155 | Ki | 6.64 | 6.64 | 226.3 | 1 |
| Alpha-2C adrenergic receptor CHEMBL1916 | Ki | 6.64 | 6.64 | 230.0 | 1 |
| D(3) dopamine receptor CHEMBL234 | Ki | 6.42 | 5.3 | 380.2 | 12 |
| D(2) dopamine receptor CHEMBL217 | Ki | 6.35 | 5.3671 | 448.0 | 21 |
| 5-hydroxytryptamine receptor 6 CHEMBL3371 | Ki | 5.78 | 5.78 | 1656.2 | 1 |
| Alpha-1A adrenergic receptor CHEMBL229 | Ki | 5.66 | 5.66 | 2200.0 | 1 |
| Alpha-1B adrenergic receptor CHEMBL232 | Ki | 5.54 | 5.54 | 2900.0 | 1 |
| D(2) dopamine receptor CHEMBL3998 | Ki | 5.21 | 5.21 | 6100.0 | 1 |
| 5-hydroxytryptamine receptor 1A CHEMBL214 | Ki | 5.18 | 5.145 | 6620.9 | 2 |
| Voltage-gated L-type calcium channel CHEMBL2095229 | IC50 | 5.05 | 5.05 | 9000.0 | 1 |
| D(1A) dopamine receptor CHEMBL2967 | Ki | 5.0 | 5.0 | 9900.0 | 3 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| F | 66.0 | % | Rattus norvegicus |
| F | 20.0 | % | Macaca mulatta |
| F | 66.0 | % | Rattus norvegicus |
| F | 20.0 | % | Macaca mulatta |
| T1/2 | 3.0 | hr | Rattus norvegicus |
| T1/2 | 2.1 | hr | Rattus norvegicus |
| T1/2 | 2.1 | hr | Rattus norvegicus |
| T1/2 | 2.8 | hr | Macaca mulatta |
| T1/2 | 2.8 | hr | Macaca mulatta |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine