Assay Detail
Binding
CHEMBL885353
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Ability to displace [3H]spiperone from cloned human dopamine D4 receptor stably expressed in HEK293 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and sar of 2- and 3-substituted 7-azaindoles as potential dopamine D4 ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.16 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267014 | L-745870 | — | 1 | 9.37 |
| CHEMBL28607 | — | — | 1 | 8.89 |
| CHEMBL155207 | — | — | 1 | 8.74 |
| CHEMBL156732 | — | — | 1 | 8.70 |
| CHEMBL2112913 | — | — | 1 | 8.19 |
| CHEMBL154286 | — | — | 1 | 8.15 |
| CHEMBL347155 | — | — | 1 | 7.93 |
| CHEMBL347291 | — | — | 1 | 7.58 |
| CHEMBL154482 | — | — | 1 | 7.52 |
| CHEMBL2112912 | — | — | 1 | 7.47 |
| CHEMBL156896 | — | — | 1 | 7.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267014 | L-745870 | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL28607 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL155207 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL156732 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL2112913 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL154286 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL347155 | — | Ki | = | 11.7 | nM | 7.93 |
| CHEMBL347291 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL154482 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL2112912 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL156896 | — | Ki | = | 59.0 | nM | 7.23 |