Assay Detail
Binding
CHEMBL4039190
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Inhibition of human dopamine D4 receptor
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Return of D4 Dopamine Receptor Antagonists in Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 8.46 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4096543 | — | — | 1 | 9.48 |
| CHEMBL267014 | L-745870 | — | 1 | 9.37 |
| CHEMBL127257 | — | — | 1 | 8.82 |
| CHEMBL320597 | — | — | 1 | 8.70 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.64 |
| CHEMBL444309 | — | — | 1 | 8.60 |
| CHEMBL4080034 | — | — | 1 | 8.55 |
| CHEMBL81330 | — | — | 1 | 8.52 |
| CHEMBL69759 | SONEPIPRAZOLE | 2.0 | 1 | 8.44 |
| CHEMBL305276 | — | — | 1 | 8.40 |
| CHEMBL4066603 | — | — | 1 | 8.31 |
| CHEMBL4104272 | — | — | 1 | 8.25 |
| CHEMBL126429 | — | — | 1 | 8.22 |
| CHEMBL4069306 | — | — | 1 | 8.21 |
| CHEMBL4095082 | — | — | 1 | 8.06 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.00 |
| CHEMBL303692 | — | — | 1 | 7.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4096543 | — | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL267014 | L-745870 | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL127257 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL320597 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL444309 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL4080034 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL81330 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL69759 | SONEPIPRAZOLE | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL305276 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL4066603 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL4104272 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL126429 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL4069306 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL4095082 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL42 | CLOZAPINE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL303692 | — | Ki | = | 59.0 | nM | 7.23 |