Compound Detail
CHEMBL305276
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Basic Information
| ChEMBL ID | CHEMBL305276 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UFFVYLYYQFBQCZ-UHFFFAOYSA-N |
4
Targets
8
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
369.9
MW (Da)
3.05
ALogP
3
HBA
0
HBD
26.8
PSA (Ų)
0.83
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 8 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(4) dopamine receptor CHEMBL219 | Ki | 8.4 | 8.4 | 4.0 | 3 |
| D(2) dopamine receptor CHEMBL217 | Ki | 6.88 | 6.88 | 133.0 | 3 |
| Adrenergic receptor alpha-1 CHEMBL2094251 | Ki | 5.7 | 5.7 | 2003.0 | 1 |
| Alpha adrenergic receptor 1A and 1B CHEMBL2111476 | Ki | 5.7 | 5.7 | 2003.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(4) dopamine receptor | Ki | = | 4.0 | nM | 8.4 | Binding affinity at human Dopamine receptor D4 by [3H]- YM 09151 displacement. | 10999484 |
| D(4) dopamine receptor | Ki | = | 4.0 | nM | 8.4 | Inhibition of human dopamine D4 receptor | 28489950 |
| D(4) dopamine receptor | Ki | = | 4.0 | nM | 8.4 | Binding affinity to D4R (unknown origin) assessed as inhibition constant | 33422983 |
| D(2) dopamine receptor | Ki | = | 133.0 | nM | 6.88 | Binding affinity at human Dopamine receptor D2 by [3H]- YM 09151 displacement. | 10999484 |
| D(2) dopamine receptor | Ki | = | 133.0 | nM | 6.88 | Inhibition of human dopamine D2 receptor | 28489950 |
| D(2) dopamine receptor | Ki | = | 133.0 | nM | 6.88 | Binding affinity to D2R (unknown origin) assessed as inhibition constant | 33422983 |
| Alpha adrenergic receptor 1A and 1B | Ki | = | 2003.0 | nM | 5.7 | Binding affinity at Alpha-1 adrenergic receptor in rat brain homogenates by [3H]... | 10999484 |
| Adrenergic receptor alpha-1 | Ki | = | 2003.0 | nM | 5.7 | Inhibition of alpha1 adrenergic receptor (unknown origin) | 28489950 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10999484 | 10.1016/s0960-894x(00)00421-2 | D(2) dopamine receptor | 2 |
| 10999484 | 10.1016/s0960-894x(00)00421-2 | D(4) dopamine receptor | 2 |
| 10999484 | 10.1016/s0960-894x(00)00421-2 | Alpha adrenergic receptor 1A and 1B | 1 |
| 28489950 | 10.1021/acs.jmedchem.7b00151 | D(2) dopamine receptor | 1 |
| 28489950 | 10.1021/acs.jmedchem.7b00151 | Adrenergic receptor alpha-1 | 1 |
| 28489950 | 10.1021/acs.jmedchem.7b00151 | D(4) dopamine receptor | 1 |
| 33422983 | 10.1016/j.ejmech.2020.113141 | D(2) dopamine receptor | 1 |
| 33422983 | 10.1016/j.ejmech.2020.113141 | D(4) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine