Assay Detail
Binding
CHEMBL4039182
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Inhibition of alpha1 adrenergic receptor (unknown origin)
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Return of D4 Dopamine Receptor Antagonists in Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.27 | 7.42 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81330 | — | — | 1 | 7.42 |
| CHEMBL146556 | — | — | 1 | 6.01 |
| CHEMBL320597 | — | — | 1 | 5.95 |
| CHEMBL305276 | — | — | 1 | 5.70 |
| CHEMBL103772 | — | — | 1 | - |
| CHEMBL303692 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81330 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL146556 | — | Ki | = | 967.0 | nM | 6.01 |
| CHEMBL320597 | — | Ki | = | 1118.0 | nM | 5.95 |
| CHEMBL305276 | — | Ki | = | 2003.0 | nM | 5.70 |
| CHEMBL103772 | — | Inhibition | < | 50.0 | % | - |
| CHEMBL303692 | — | Ki | > | 10000.0 | nM | - |