Assay Detail
Binding
CHEMBL675855
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at human Dopamine receptor D4 by [3H]- YM 09151 displacement.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and discovery of 3-piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives: a novel series of mixed dopamine D2/D4 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.95 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69584 | — | — | 1 | 8.80 |
| CHEMBL305276 | — | — | 1 | 8.40 |
| CHEMBL68191 | — | — | 1 | 8.40 |
| CHEMBL302075 | — | — | 1 | 8.30 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.77 |
| CHEMBL303692 | — | — | 1 | 7.23 |
| CHEMBL67222 | — | — | 1 | 7.00 |
| CHEMBL67414 | — | — | 1 | 5.82 |
| CHEMBL63209 | — | — | 1 | 5.61 |
| CHEMBL302340 | — | — | 1 | 5.53 |
| CHEMBL305061 | — | — | 1 | 5.36 |
| CHEMBL304584 | — | — | 1 | 5.15 |
| CHEMBL67429 | — | — | 1 | - |
| CHEMBL305453 | — | — | 1 | - |
| CHEMBL68190 | — | — | 1 | - |
| CHEMBL67042 | — | — | 1 | - |
| CHEMBL303406 | — | — | 1 | - |
| CHEMBL304777 | — | — | 1 | - |
| CHEMBL66957 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69584 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL305276 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL68191 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL302075 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL42 | CLOZAPINE | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL303692 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL67222 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL67414 | — | Ki | = | 1511.0 | nM | 5.82 |
| CHEMBL63209 | — | Ki | = | 2469.0 | nM | 5.61 |
| CHEMBL302340 | — | Ki | = | 2960.0 | nM | 5.53 |
| CHEMBL305061 | — | Ki | = | 4377.0 | nM | 5.36 |
| CHEMBL304584 | — | Ki | = | 7018.0 | nM | 5.15 |
| CHEMBL67429 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL305453 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL68190 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL67042 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL303406 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL304777 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL66957 | — | Ki | > | 1000.0 | nM | - |