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Compound Detail

CHEMBL304584

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CCN1C(=O)C(CC)(N2CCN(Cc3ccc(Cl)cc3)CC2)c2ccccc21

Basic Information

ChEMBL ID CHEMBL304584
Phase Preclinical
Structure Type MOL
InChI Key UTXCMSKCFYPXAI-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

397.9
MW (Da)
4.13
ALogP
3
HBA
0
HBD
26.8
PSA (Ų)
0.76
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H28ClN3O
MW 397.95
Aromatic Rings 2
Heavy Atoms 28
NP-Likeness -0.97

Activity Summary

Ki 1 meas. best 5.15

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(4) dopamine receptor
CHEMBL219
Ki 5.15 5.15 7018.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
D(4) dopamine receptor Ki = 7018.0 nM 5.15 Binding affinity at human Dopamine receptor D4 by [3H]- YM 09151 displacement. 10999484

Literature References

PubMed DOI Target Context # Activities
10999484 10.1016/s0960-894x(00)00421-2 D(2) dopamine receptor 1
10999484 10.1016/s0960-894x(00)00421-2 D(4) dopamine receptor 1
10999484 10.1016/s0960-894x(00)00421-2 Alpha adrenergic receptor 1A and 1B 1

Data from ChEMBL 36 via Core Engine