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Compound Detail

CHEMBL68191

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CCN1C(=O)C(N2CCN(Cc3ccc(Cl)cc3)CC2)Cc2ccccc21

Basic Information

ChEMBL ID CHEMBL68191
Phase Preclinical
Structure Type MOL
InChI Key BZWQAKCTTBOIKJ-UHFFFAOYSA-N
4
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

383.9
MW (Da)
3.44
ALogP
3
HBA
0
HBD
26.8
PSA (Ų)
0.81
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H26ClN3O
MW 383.92
Aromatic Rings 2
Heavy Atoms 27
NP-Likeness -1.22

Activity Summary

Ki 6 meas. best 8.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(4) dopamine receptor
CHEMBL219
Ki 8.4 8.4 4.0 2
D(2) dopamine receptor
CHEMBL217
Ki 7.68 7.68 21.0 2
Adrenergic receptor alpha-1
CHEMBL1907610
Ki 5.9 5.9 1265.0 1
Alpha adrenergic receptor 1A and 1B
CHEMBL2111476
Ki 5.9 5.9 1265.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
12639562 10.1016/s0960-894x(02)01056-9 D(2) dopamine receptor 1
12639562 10.1016/s0960-894x(02)01056-9 D(4) dopamine receptor 1
12639562 10.1016/s0960-894x(02)01056-9 Adrenergic receptor alpha-1 1
10999484 10.1016/s0960-894x(00)00421-2 D(2) dopamine receptor 1
10999484 10.1016/s0960-894x(00)00421-2 D(4) dopamine receptor 1
10999484 10.1016/s0960-894x(00)00421-2 Alpha adrenergic receptor 1A and 1B 1

Data from ChEMBL 36 via Core Engine