Assay Detail
Binding
CHEMBL674047
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-YM 09151 from D4 receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and discovery of 5-piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives: a novel series of mixed dopamine D2/D4 receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.80 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69584 | — | — | 1 | 8.80 |
| CHEMBL351963 | — | — | 1 | 8.40 |
| CHEMBL68191 | — | — | 1 | 8.40 |
| CHEMBL352207 | — | — | 1 | 8.30 |
| CHEMBL349833 | — | — | 1 | 8.05 |
| CHEMBL345438 | — | — | 1 | 8.00 |
| CHEMBL351989 | — | — | 1 | 7.92 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.77 |
| CHEMBL439646 | — | — | 1 | 7.72 |
| CHEMBL354699 | — | — | 1 | 7.54 |
| CHEMBL159742 | — | — | 1 | 7.47 |
| CHEMBL351612 | — | — | 1 | 7.19 |
| CHEMBL67414 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69584 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL351963 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL68191 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL352207 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL349833 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL345438 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL351989 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL42 | CLOZAPINE | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL439646 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL354699 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL159742 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL351612 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL67414 | — | Ki | = | 1511.0 | nM | 5.82 |