Alpha adrenergic receptor 1A and 1B · SELECTIVITY GROUP · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P15823. Use UniProt P15823 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P15823 as the stable identity anchor, then attach disease evidence before program review.
Alpha-1B adrenergic receptor
Review this target as Alpha adrenergic receptor 1A and 1B, mapped to UniProt P15823. ChEMBL maps the protein component as Alpha-1B adrenergic receptor. Sequence length is 515 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Alpha adrenergic receptor 1A and 1B as ChEMBL target CHEMBL2111476, mapped to UniProt P15823. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Alpha adrenergic receptor 1A and 1B |
| Target Type | SELECTIVITY GROUP |
| Organism | Rattus norvegicus |
| UniProt | P15823 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Alpha-1B adrenergic receptor |
| UniProt Accession | P15823 |
| Component Type | Protein |
| Sequence Length | 515 aa |
Alpha-1B adrenergic receptor
Review this target as Alpha adrenergic receptor 1A and 1B, mapped to UniProt P15823. ChEMBL maps the protein component as Alpha-1B adrenergic receptor. Sequence length is 515 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL42 | 8.4 | Ki | 4.0 | Approved |
| CHEMBL276175 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL69584 | 7.06 | Ki | 88.0 | Preclinical |
| CHEMBL302075 | 6.49 | Ki | 322.0 | Preclinical |
| CHEMBL302340 | 6.09 | Ki | 815.0 | Preclinical |
| CHEMBL68191 | 5.9 | Ki | 1265.0 | Preclinical |
| CHEMBL67222 | 5.7 | Ki | 2003.0 | Preclinical |
| CHEMBL305276 | 5.7 | Ki | 2003.0 | Preclinical |
| CHEMBL305061 | 5.69 | Ki | 2038.0 | Preclinical |
| CHEMBL67414 | 5.57 | Ki | 2678.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 4 | 0 | — |
| assay format | 1 | 1 | 8.0 |
| tissue-based format | 1 | 12 | 6.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 0 | — |