Compound Detail
CHEMBL69759
SONEPIPRAZOLE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL69759 |
| Name | SONEPIPRAZOLE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | WNUQCGWXPNGORO-NRFANRHFSA-N |
5
Targets
6
Activities
1
Assay Types
0
PK Parameters
20
Publications
3
Known Names
Molecular Properties
401.5
MW (Da)
2.16
ALogP
5
HBA
1
HBD
75.9
PSA (Ų)
0.83
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Activity Summary
Ki 6 meas. best 8.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(4) dopamine receptor CHEMBL219 | Ki | 8.44 | 8.305 | 3.6 | 2 |
| D(4) dopamine receptor CHEMBL3361 | Ki | 8.14 | 8.14 | 7.2 | 1 |
| Unchecked CHEMBL612545 | Ki | 8.0 | 8.0 | 10.1 | 1 |
| D(2) dopamine receptor CHEMBL217 | Ki | 5.29 | 5.29 | 5147.0 | 1 |
| D(3) dopamine receptor CHEMBL3138 | Ki | 5.24 | 5.24 | 5800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(4) dopamine receptor | Ki | = | 3.6 | nM | 8.44 | Inhibition of human dopamine D4 receptor | 28489950 |
| D(4) dopamine receptor | Ki | = | 6.8 | nM | 8.17 | Binding affinity towards human dopamine receptor D4 | 11170639 |
| D(4) dopamine receptor | Ki | = | 7.2 | nM | 8.14 | Binding affinity of [3H]spiperone towards Dopamine receptor D4 expressed in cult... | 8691438 |
| Unchecked | Ki | = | 10.1 | nM | 8.0 | Inhibition of human dopamine D4.2 receptor | 28489950 |
| D(2) dopamine receptor | Ki | = | 5147.0 | nM | 5.29 | Inhibition of human dopamine D2 receptor | 28489950 |
| D(3) dopamine receptor | Ki | = | 5800.0 | nM | 5.24 | Binding affinity of [3H]spiperone towards Dopamine receptor D3 in cloned mammali... | 8691438 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11170639 | 10.1021/jm0002432 | Rodentia sp. | 6 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 10999484 | 10.1016/s0960-894x(00)00421-2 | D(2) dopamine receptor | 1 |
| 28489950 | 10.1021/acs.jmedchem.7b00151 | D(4) dopamine receptor | 1 |
| 28489950 | 10.1021/acs.jmedchem.7b00151 | Histamine H1 receptor | 1 |
| 28489950 | 10.1021/acs.jmedchem.7b00151 | Alpha-2A adrenergic receptor | 1 |
| 28489950 | 10.1021/acs.jmedchem.7b00151 | 5-hydroxytryptamine receptor 2A | 1 |
| 28489950 | 10.1021/acs.jmedchem.7b00151 | 5-hydroxytryptamine receptor 1A | 1 |
| 28489950 | 10.1021/acs.jmedchem.7b00151 | D(3) dopamine receptor | 1 |
| 28489950 | 10.1021/acs.jmedchem.7b00151 | D(2) dopamine receptor | 1 |
| 28489950 | 10.1021/acs.jmedchem.7b00151 | D(1A) dopamine receptor | 1 |
| 10999484 | 10.1016/s0960-894x(00)00421-2 | D(4) dopamine receptor | 1 |
| 8691438 | 10.1021/jm960084f | D(1A) dopamine receptor | 1 |
| 11170639 | 10.1021/jm0002432 | D(4) dopamine receptor | 1 |
| 8691438 | 10.1021/jm960084f | Adrenergic receptor alpha-2 | 1 |
| 8691438 | 10.1021/jm960084f | Adrenergic receptor alpha-1 | 1 |
| 8691438 | 10.1021/jm960084f | Serotonin 2 (5-HT2) receptor | 1 |
| 8691438 | 10.1021/jm960084f | 5-hydroxytryptamine receptor 1A | 1 |
| 8691438 | 10.1021/jm960084f | D(4) dopamine receptor | 1 |
| 8691438 | 10.1021/jm960084f | D(3) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine