Assay Detail
Binding
CHEMBL671597
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Binding affinity of [3H]spiperone towards Dopamine receptor D4 expressed in cultured cells or from rat whole brain.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.95 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71724 | — | — | 1 | 8.85 |
| CHEMBL309730 | — | — | 1 | 8.66 |
| CHEMBL81330 | — | — | 1 | 8.52 |
| CHEMBL69759 | SONEPIPRAZOLE | 2.0 | 1 | 8.14 |
| CHEMBL63329 | — | — | 1 | 7.68 |
| CHEMBL83915 | — | — | 1 | 7.62 |
| CHEMBL82591 | — | — | 1 | 7.60 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.50 |
| CHEMBL81649 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71724 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL309730 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL81330 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL69759 | SONEPIPRAZOLE | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL63329 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL83915 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL82591 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL42 | CLOZAPINE | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL81649 | — | Ki | = | 100.0 | nM | 7.00 |