Assay Detail
Binding
CHEMBL674593
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Binding affinity of [3H]spiperone towards Dopamine receptor D3 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.98 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL82591 | — | — | 1 | 6.66 |
| CHEMBL81330 | — | — | 1 | 6.62 |
| CHEMBL71724 | — | — | 1 | 5.92 |
| CHEMBL309730 | — | — | 1 | 5.89 |
| CHEMBL81649 | — | — | 1 | 5.54 |
| CHEMBL69759 | SONEPIPRAZOLE | 2.0 | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL82591 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL81330 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL71724 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL309730 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL81649 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL69759 | SONEPIPRAZOLE | Ki | = | 5800.0 | nM | 5.24 |