Assay Detail
Binding
CHEMBL675946
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards human dopamine receptor D4
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Current and novel approaches to the drug treatment of schizophrenia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.89 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267014 | L-745870 | — | 1 | 9.37 |
| CHEMBL357182 | — | — | 1 | 8.72 |
| CHEMBL83894 | FANANSERIN | 2.0 | 1 | 8.54 |
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 8.46 |
| CHEMBL444309 | — | — | 1 | 8.46 |
| CHEMBL103772 | — | — | 1 | 8.44 |
| CHEMBL422314 | — | — | 1 | 8.37 |
| CHEMBL6416 | — | — | 1 | 8.26 |
| CHEMBL148561 | — | — | 1 | 8.24 |
| CHEMBL69759 | SONEPIPRAZOLE | 2.0 | 1 | 8.17 |
| CHEMBL37170 | — | — | 1 | 8.11 |
| CHEMBL59324 | — | — | 1 | 8.10 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 7.80 |
| CHEMBL59103 | — | — | 1 | 7.60 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 7.55 |
| CHEMBL708 | ZIPRASIDONE | 4.0 | 1 | 7.41 |
| CHEMBL285802 | ZOTEPINE | 2.0 | 1 | 7.41 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.40 |
| CHEMBL61080 | — | — | 1 | 7.21 |
| CHEMBL57478 | — | — | 1 | 6.24 |
| CHEMBL716 | QUETIAPINE | 4.0 | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267014 | L-745870 | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL357182 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL83894 | FANANSERIN | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL51 | KETANSERIN | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL444309 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL103772 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL422314 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL6416 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL148561 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL69759 | SONEPIPRAZOLE | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL37170 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL59324 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL85 | RISPERIDONE | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL59103 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL715 | OLANZAPINE | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL708 | ZIPRASIDONE | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL285802 | ZOTEPINE | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL42 | CLOZAPINE | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL61080 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL57478 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL716 | QUETIAPINE | Ki | = | 1600.0 | nM | 5.80 |