Assay Detail
Binding
CHEMBL4039161
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Inhibition of human dopamine D4.4 receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Return of D4 Dopamine Receptor Antagonists in Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.47 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267014 | L-745870 | — | 1 | 9.37 |
| CHEMBL310843 | — | — | 1 | 8.66 |
| CHEMBL103772 | — | — | 1 | 8.66 |
| CHEMBL146556 | — | — | 1 | 8.62 |
| CHEMBL66227 | — | — | 1 | 8.47 |
| CHEMBL7927 | FAUC 113 | — | 1 | 8.44 |
| CHEMBL346389 | — | — | 1 | 8.37 |
| CHEMBL3335537 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267014 | L-745870 | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL310843 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL103772 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL146556 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL66227 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL7927 | FAUC 113 | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL346389 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL3335537 | — | Ki | = | 70.0 | nM | 7.16 |