Serotonin 2 (5-HT2) receptor · PROTEIN FAMILY · Homo sapiens
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As of 2026-09-13Serotonin 2 (5-HT2) receptor shows approved-linked disease relevance led by major depressive disorder. 1 more disease program remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P41595. Start with major depressive disorder, then reuse UniProt P41595 as the stable protein anchor across project notes and exports.
Start with major depressive disorder, then reuse UniProt P41595 as the stable protein anchor across project notes and exports.
Serotonin 2 (5-HT2) receptor shows approved-linked disease relevance led by major depressive disorder. 1 more disease program remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with major depressive disorder because it currently carries approved-linked support. Linked drugs include MINAPRINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxy5-hydroxytryptamine receptor 2B
Review this target as Serotonin 2 (5-HT2) receptor, mapped to UniProt P41595. ChEMBL maps the protein component as 5-hydroxytryptamine receptor 2B. Sequence length is 481 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Serotonin 2 (5-HT2) receptor as ChEMBL target CHEMBL2095200, mapped to UniProt P41595. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Serotonin 2 (5-HT2) receptor is the right protein anchor across sources, using UniProt P41595 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why major depressive disorder is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.
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| Preferred Name | Serotonin 2 (5-HT2) receptor |
| Target Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
| UniProt | P41595 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5-hydroxytryptamine receptor 2B |
| UniProt Accession | P41595 |
| Component Type | Protein |
| Sequence Length | 481 aa |
5-hydroxytryptamine receptor 2B
Review this target as Serotonin 2 (5-HT2) receptor, mapped to UniProt P41595. ChEMBL maps the protein component as 5-hydroxytryptamine receptor 2B. Sequence length is 481 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Serotonin 2 (5-HT2) receptor shows approved-linked disease relevance led by major depressive disorder. 1 more disease program remain visible in the same review block.
Start review with major depressive disorder because it currently carries approved-linked support. Linked drugs include MINAPRINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5204619 | 9.3 | Ki | 0.5 | Preclinical |
| CHEMBL45491 | 9.24 | Ki | 0.57 | Preclinical |
| CHEMBL300647 | 9.0 | Ki | 1.0 | Preclinical |
| CHEMBL257704 | 8.92 | Kd | 1.2 | Clinical |
| CHEMBL1423 | 8.57 | IC50 | 2.7 | Approved |
| CHEMBL542942 | 8.38 | Ki | 4.2 | Preclinical |
| CHEMBL42 | 8.3 | Ki | 5.012 | Approved |
| CHEMBL1729 | 8.21 | IC50 | 6.1 | Approved |
| CHEMBL330865 | 8.15 | Ki | 7.0 | Preclinical |
| CHEMBL331470 | 8.15 | Ki | 7.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 39 | 79 | 6.6 |
| cell-based format | 6 | 14 | 6.8 |
| tissue-based format | 4 | 37 | 6.9 |
| assay format | 1 | 6 | 5.8 |
| cell membrane format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 9 | 0 | — |
| organism-based format | 6 | 0 | — |