Compound Detail
CHEMBL257704
EPLIVANSERIN 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL257704 |
| Name | EPLIVANSERIN |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | VAIOZOCLKVMIMN-PRJWTAEASA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
7
Publications
5
Known Names
2
Indications
1
Mechanisms
Molecular Properties
328.4
MW (Da)
3.53
ALogP
4
HBA
1
HBD
45.1
PSA (Ų)
0.48
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Serotonin 2a (5-HT2a) receptor antagonist | ANTAGONIST | 5-hydroxytryptamine receptor 2A | ✓ | ✓ |
Indications
Sleep Initiation and Maintenance Disorders Sleep Wake Disorders
Activity Summary
Kd 1 meas. best 8.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serotonin 2 (5-HT2) receptor CHEMBL2095200 | Kd | 8.92 | 8.92 | 1.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serotonin 2 (5-HT2) receptor | Kd | = | 1.2 | nM | 8.92 | Binding affinity to 5-HT2 receptor (unknown origin) assessed as dissociation con... | 35939391 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 18282705 | 10.1016/j.bmcl.2008.01.090 | 5-hydroxytryptamine receptor 2B | 1 |
| 18282705 | 10.1016/j.bmcl.2008.01.090 | 5-hydroxytryptamine receptor 2C | 1 |
| 18282705 | 10.1016/j.bmcl.2008.01.090 | 5-hydroxytryptamine receptor 2A | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| 35939391 | 10.1021/acs.jmedchem.2c00633 | Serotonin 2 (5-HT2) receptor | 1 |
Data from ChEMBL 36 via Core Engine