Assay Detail
Binding
CHEMBL674966
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In vitro binding affinity was measured at the cloned human Dopamine receptor D4.2 using [3H]YM-09151-2 as radioligand.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.79 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267014 | L-745870 | — | 1 | 9.37 |
| CHEMBL28321 | — | — | 1 | 9.15 |
| CHEMBL148024 | — | — | 1 | 8.52 |
| CHEMBL283353 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267014 | L-745870 | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL28321 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL148024 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL283353 | — | Ki | = | 8.0 | nM | 8.10 |