Assay Detail
Binding
CHEMBL675944
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In vitro binding affinity at human dopamine D4 receptor expressed in CHO cells by [3H]spiperone displacement.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Isoindolinone enantiomers having affinity for the dopamine D4 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.68 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267014 | L-745870 | — | 1 | 9.04 |
| CHEMBL37170 | — | — | 1 | 8.11 |
| CHEMBL37885 | — | — | 1 | 8.07 |
| CHEMBL38262 | — | — | 1 | 8.06 |
| CHEMBL37604 | — | — | 1 | 8.03 |
| CHEMBL37169 | — | — | 1 | 8.00 |
| CHEMBL36313 | — | — | 1 | 7.96 |
| CHEMBL287078 | — | — | 1 | 7.91 |
| CHEMBL38349 | — | — | 1 | 7.68 |
| CHEMBL37638 | — | — | 1 | 7.65 |
| CHEMBL34239 | — | — | 1 | 7.61 |
| CHEMBL290351 | — | — | 1 | 7.56 |
| CHEMBL35182 | — | — | 1 | 7.46 |
| CHEMBL37706 | — | — | 1 | 7.43 |
| CHEMBL35093 | — | — | 1 | 7.38 |
| CHEMBL285543 | — | — | 1 | 7.22 |
| CHEMBL36337 | — | — | 1 | 7.11 |
| CHEMBL38046 | — | — | 1 | 7.09 |
| CHEMBL35114 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267014 | L-745870 | Ki | = | 0.91 | nM | 9.04 |
| CHEMBL37170 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL37885 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL38262 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL37604 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL37169 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL36313 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL287078 | — | Ki | = | 12.4 | nM | 7.91 |
| CHEMBL38349 | — | Ki | = | 20.8 | nM | 7.68 |
| CHEMBL37638 | — | Ki | = | 22.6 | nM | 7.65 |
| CHEMBL34239 | — | Ki | = | 24.5 | nM | 7.61 |
| CHEMBL290351 | — | Ki | = | 27.8 | nM | 7.56 |
| CHEMBL35182 | — | Ki | = | 35.1 | nM | 7.46 |
| CHEMBL37706 | — | Ki | = | 37.3 | nM | 7.43 |
| CHEMBL35093 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL285543 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL36337 | — | Ki | = | 78.6 | nM | 7.11 |
| CHEMBL38046 | — | Ki | = | 81.4 | nM | 7.09 |
| CHEMBL35114 | — | Ki | = | 333.0 | nM | 6.48 |