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Compound Detail

CHEMBL37638

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Cc1ccnc(N2CCN(CCC3NC(=O)c4ccccc43)CC2)c1

Basic Information

ChEMBL ID CHEMBL37638
Phase Preclinical
Structure Type MOL
InChI Key DQPPITADMDONIT-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

336.4
MW (Da)
2.39
ALogP
4
HBA
1
HBD
48.5
PSA (Ų)
0.93
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H24N4O
MW 336.44
Aromatic Rings 2
Heavy Atoms 25
NP-Likeness -1.14

Activity Summary

Ki 1 meas. best 7.65

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(4) dopamine receptor
CHEMBL219
Ki 7.65 7.65 22.6 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9873377 10.1016/s0960-894x(98)00252-2 D(2) dopamine receptor 1
9873377 10.1016/s0960-894x(98)00252-2 D(3) dopamine receptor 1
9873377 10.1016/s0960-894x(98)00252-2 D(4) dopamine receptor 1

Data from ChEMBL 36 via Core Engine