Assay Detail
Binding
CHEMBL913682
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from human dopamine D4.4 expressed in CHO cell membrane
65
Total Activities
65
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-selectivity investigations of D2-like receptor ligands by CoMFA and CoMSIA guiding the discovery of D3 selective PET radioligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 65 | 7.49 | 9.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210404 | — | — | 1 | 9.36 |
| CHEMBL221600 | — | — | 1 | 9.23 |
| CHEMBL267014 | L-745870 | — | 1 | 9.21 |
| CHEMBL141845 | — | — | 1 | 9.17 |
| CHEMBL210717 | — | — | 1 | 9.15 |
| CHEMBL210405 | — | — | 1 | 9.00 |
| CHEMBL208018 | — | — | 1 | 9.00 |
| CHEMBL160952 | — | — | 1 | 8.91 |
| CHEMBL310843 | — | — | 1 | 8.66 |
| CHEMBL7927 | FAUC 113 | — | 1 | 8.64 |
| CHEMBL425057 | — | — | 1 | 8.59 |
| CHEMBL423247 | — | — | 1 | 8.57 |
| CHEMBL210955 | — | — | 1 | 8.54 |
| CHEMBL437490 | — | — | 1 | 8.54 |
| CHEMBL221814 | — | — | 1 | 8.49 |
| CHEMBL218787 | — | — | 1 | 8.30 |
| CHEMBL377200 | — | — | 1 | 8.28 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.22 |
| CHEMBL344677 | — | — | 1 | 8.05 |
| CHEMBL424294 | — | — | 1 | 7.82 |
| CHEMBL218444 | — | — | 1 | 7.80 |
| CHEMBL221681 | — | — | 1 | 7.77 |
| CHEMBL345357 | — | — | 1 | 7.71 |
| CHEMBL220700 | — | — | 1 | 7.62 |
| CHEMBL221652 | — | — | 1 | 7.55 |
| CHEMBL139722 | — | — | 1 | 7.52 |
| CHEMBL124444 | — | — | 1 | 7.52 |
| CHEMBL221397 | — | — | 1 | 7.51 |
| CHEMBL221640 | — | — | 1 | 7.47 |
| CHEMBL25236 | BP-897 | — | 1 | 7.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210404 | — | Ki | = | 0.4365 | nM | 9.36 |
| CHEMBL221600 | — | Ki | = | 0.5888 | nM | 9.23 |
| CHEMBL267014 | L-745870 | Ki | = | 0.6166 | nM | 9.21 |
| CHEMBL141845 | — | Ki | = | 0.6761 | nM | 9.17 |
| CHEMBL210717 | — | Ki | = | 0.7079 | nM | 9.15 |
| CHEMBL210405 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL208018 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL160952 | — | Ki | = | 1.23 | nM | 8.91 |
| CHEMBL310843 | — | Ki | = | 2.188 | nM | 8.66 |
| CHEMBL7927 | FAUC 113 | Ki | = | 2.291 | nM | 8.64 |
| CHEMBL425057 | — | Ki | = | 2.57 | nM | 8.59 |
| CHEMBL423247 | — | Ki | = | 2.692 | nM | 8.57 |
| CHEMBL210955 | — | Ki | = | 2.884 | nM | 8.54 |
| CHEMBL437490 | — | Ki | = | 2.884 | nM | 8.54 |
| CHEMBL221814 | — | Ki | = | 3.236 | nM | 8.49 |
| CHEMBL218787 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL377200 | — | Ki | = | 5.248 | nM | 8.28 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 6.026 | nM | 8.22 |
| CHEMBL344677 | — | Ki | = | 8.913 | nM | 8.05 |
| CHEMBL424294 | — | Ki | = | 15.14 | nM | 7.82 |
| CHEMBL218444 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL221681 | — | Ki | = | 16.98 | nM | 7.77 |
| CHEMBL345357 | — | Ki | = | 19.5 | nM | 7.71 |
| CHEMBL220700 | — | Ki | = | 23.99 | nM | 7.62 |
| CHEMBL221652 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL139722 | — | Ki | = | 30.2 | nM | 7.52 |
| CHEMBL124444 | — | Ki | = | 30.2 | nM | 7.52 |
| CHEMBL221397 | — | Ki | = | 30.9 | nM | 7.51 |
| CHEMBL221640 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL25236 | BP-897 | Ki | = | 38.9 | nM | 7.41 |
| CHEMBL221129 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL218638 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL357684 | — | Ki | = | 40.74 | nM | 7.39 |
| CHEMBL217981 | — | Ki | = | 41.69 | nM | 7.38 |
| CHEMBL218318 | — | Ki | = | 44.67 | nM | 7.35 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 57.54 | nM | 7.24 |
| CHEMBL376020 | — | Ki | = | 57.54 | nM | 7.24 |
| CHEMBL139600 | — | Ki | = | 67.61 | nM | 7.17 |
| CHEMBL342060 | — | Ki | = | 67.61 | nM | 7.17 |
| CHEMBL386986 | — | Ki | = | 75.86 | nM | 7.12 |
| CHEMBL140968 | — | Ki | = | 77.62 | nM | 7.11 |
| CHEMBL143352 | — | Ki | = | 87.1 | nM | 7.06 |
| CHEMBL385289 | — | Ki | = | 91.2 | nM | 7.04 |
| CHEMBL139926 | — | Ki | = | 93.33 | nM | 7.03 |
| CHEMBL142020 | — | Ki | = | 128.82 | nM | 6.89 |
| CHEMBL218351 | — | Ki | = | 128.82 | nM | 6.89 |
| CHEMBL218368 | — | Ki | = | 151.36 | nM | 6.82 |
| CHEMBL221587 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL221549 | — | Ki | = | 169.82 | nM | 6.77 |
| CHEMBL218203 | — | Ki | = | 199.53 | nM | 6.70 |