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Compound Detail

CHEMBL218787

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Clc1ccc(N2CCN(Cc3cnn4c(I)cccc34)CC2)cc1

Basic Information

ChEMBL ID CHEMBL218787
Phase Preclinical
Structure Type MOL
InChI Key DQWYVTVADJXAAR-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

452.7
MW (Da)
3.91
ALogP
4
HBA
0
HBD
23.8
PSA (Ų)
0.44
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H18ClIN4
MW 452.73
Aromatic Rings 3
Heavy Atoms 24
NP-Likeness -1.73

Activity Summary

Ki 3 meas. best 8.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(4) dopamine receptor
CHEMBL219
Ki 8.3 8.3 5.0 1
D(3) dopamine receptor
CHEMBL234
Ki 5.57 5.57 2691.5 1
D(2) dopamine receptor
CHEMBL217
Ki 5.12 5.12 7585.8 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11312915 10.1021/jm001055e D(4) dopamine receptor 1
17266201 10.1021/jm0611152 Dopamine receptors; D2 & D3 1
17266201 10.1021/jm0611152 Dopamine receptors; D3 & D4 1
17266201 10.1021/jm0611152 D(3) dopamine receptor 1
17266201 10.1021/jm0611152 D(4) dopamine receptor 1
17266201 10.1021/jm0611152 D(2) dopamine receptor 1

Data from ChEMBL 36 via Core Engine