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Assay Detail

CHEMBL913685

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Binding
Binding affinity to dopamine D2
ChEMBL ↗
63
Total Activities
63
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

D(2) dopamine receptor (CHEMBL217) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure-selectivity investigations of D2-like receptor ligands by CoMFA and CoMSIA guiding the discovery of D3 selective PET radioligands.
Salama I, Hocke C, Utz W, Prante O, Boeckler F, Hübner H, Kuwert T, Gmeiner P.
J Med Chem (2007) 50 : 489 -500
PubMed 17266201 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 63 6.73 8.95

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL54 HALOPERIDOL 4.0 1 8.95
CHEMBL1112 ARIPIPRAZOLE 4.0 1 8.74
CHEMBL217981 — — 1 8.31
CHEMBL221129 — — 1 8.28
CHEMBL221866 — — 1 8.04
CHEMBL221587 — — 1 8.03
CHEMBL221897 — — 1 8.00
CHEMBL425285 — — 1 7.85
CHEMBL220754 — — 1 7.77
CHEMBL386986 — — 1 7.66
CHEMBL139600 — — 1 7.52
CHEMBL221600 — — 1 7.42
CHEMBL373873 — — 1 7.41
CHEMBL210404 — — 1 7.40
CHEMBL218351 — — 1 7.37
CHEMBL437525 — — 1 7.26
CHEMBL218607 — — 1 7.24
CHEMBL385289 — — 1 7.21
CHEMBL210717 — — 1 7.20
CHEMBL218318 — — 1 7.17
CHEMBL140968 — — 1 7.15
CHEMBL208018 — — 1 7.15
CHEMBL424294 — — 1 7.06
CHEMBL221681 — — 1 7.02
CHEMBL218444 — — 1 6.96
CHEMBL124444 — — 1 6.96
CHEMBL376020 — — 1 6.89
CHEMBL374749 — — 1 6.89
CHEMBL210405 — — 1 6.85
CHEMBL220700 — — 1 6.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL54 HALOPERIDOL Ki = 1.122 nM 8.95
CHEMBL1112 ARIPIPRAZOLE Ki = 1.82 nM 8.74
CHEMBL217981 — Ki = 4.898 nM 8.31
CHEMBL221129 — Ki = 5.248 nM 8.28
CHEMBL221866 — Ki = 9.12 nM 8.04
CHEMBL221587 — Ki = 9.333 nM 8.03
CHEMBL221897 — Ki = 10.0 nM 8.00
CHEMBL425285 — Ki = 14.13 nM 7.85
CHEMBL220754 — Ki = 16.98 nM 7.77
CHEMBL386986 — Ki = 21.88 nM 7.66
CHEMBL139600 — Ki = 30.2 nM 7.52
CHEMBL221600 — Ki = 38.02 nM 7.42
CHEMBL373873 — Ki = 38.9 nM 7.41
CHEMBL210404 — Ki = 39.81 nM 7.40
CHEMBL218351 — Ki = 42.66 nM 7.37
CHEMBL437525 — Ki = 54.95 nM 7.26
CHEMBL218607 — Ki = 57.54 nM 7.24
CHEMBL385289 — Ki = 61.66 nM 7.21
CHEMBL210717 — Ki = 63.1 nM 7.20
CHEMBL218318 — Ki = 67.61 nM 7.17
CHEMBL140968 — Ki = 70.79 nM 7.15
CHEMBL208018 — Ki = 70.79 nM 7.15
CHEMBL424294 — Ki = 87.1 nM 7.06
CHEMBL221681 — Ki = 95.5 nM 7.02
CHEMBL124444 — Ki = 109.65 nM 6.96
CHEMBL218444 — Ki = 109.65 nM 6.96
CHEMBL376020 — Ki = 128.82 nM 6.89
CHEMBL374749 — Ki = 128.82 nM 6.89
CHEMBL210405 — Ki = 141.25 nM 6.85
CHEMBL220700 — Ki = 141.25 nM 6.85
CHEMBL344677 — Ki = 151.36 nM 6.82
CHEMBL218638 — Ki = 158.49 nM 6.80
CHEMBL342060 — Ki = 190.55 nM 6.72
CHEMBL218368 — Ki = 199.53 nM 6.70
CHEMBL25236 BP-897 Ki = 208.93 nM 6.68
CHEMBL221814 — Ki = 218.78 nM 6.66
CHEMBL221843 — Ki = 229.09 nM 6.64
CHEMBL143352 — Ki = 269.15 nM 6.57
CHEMBL221549 — Ki = 281.84 nM 6.55
CHEMBL141845 — Ki = 288.4 nM 6.54
CHEMBL142020 — Ki = 309.03 nM 6.51
CHEMBL139926 — Ki = 323.59 nM 6.49
CHEMBL218151 — Ki = 338.84 nM 6.47
CHEMBL425057 — Ki = 338.84 nM 6.47
CHEMBL221397 — Ki = 407.38 nM 6.39
CHEMBL437490 — Ki = 446.68 nM 6.35
CHEMBL218203 — Ki = 457.09 nM 6.34
CHEMBL219274 — Ki = 467.74 nM 6.33
CHEMBL139722 — Ki = 524.81 nM 6.28
CHEMBL377200 — Ki = 630.96 nM 6.20