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Compound Detail

CHEMBL221897

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Cc1c(C(=O)NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)nnn1Cc1ccccc1

Basic Information

ChEMBL ID CHEMBL221897
Phase Preclinical
Structure Type MOL
InChI Key FYHDUYJHKIWKCX-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

515.5
MW (Da)
4.66
ALogP
6
HBA
1
HBD
66.3
PSA (Ų)
0.40
QED
1
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H32Cl2N6O
MW 515.49
Aromatic Rings 3
Heavy Atoms 35
NP-Likeness -1.96

Activity Summary

Ki 3 meas. best 8.07

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(3) dopamine receptor
CHEMBL234
Ki 8.07 8.07 8.5 1
D(2) dopamine receptor
CHEMBL217
Ki 8.0 8.0 10.0 1
D(4) dopamine receptor
CHEMBL219
Ki 6.6 6.6 251.2 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
17266201 10.1021/jm0611152 Dopamine receptors; D2 & D3 1
17266201 10.1021/jm0611152 Dopamine receptors; D3 & D4 1
17266201 10.1021/jm0611152 D(3) dopamine receptor 1
17266201 10.1021/jm0611152 D(4) dopamine receptor 1
17266201 10.1021/jm0611152 D(2) dopamine receptor 1

Data from ChEMBL 36 via Core Engine